Under the name of DOTimplantSOURCE we are providing integrated outsourcing solutions for Original Equipment Manufacturers and distributors of medical implants and associated instruments... Read more
Under the name of DOTbiomaterials we are manufacturing products of regenerative medicine ... Read more
DOT - We work on Further Solutions
We are ambitious to offer first-class solutions for medical implant coatings. To achieve this, our R & D team is permanently working on the improvement of existing and on the development of trend-setting new coatings.
In the key technology of biomaterials we are developing innovative products of regenerative medicine.
In our research activities we collaborate with well-known universities, scientific institutions and clinics, and we are part of international research networks.
Our current research activities focus on:
Antibacterial implant coatings
Implants should be mechanically stable and interconnect optimally with the autologous tissue within a short time and should not cause any foreign reactions and at least should last for a life time. An optimised adaption, especially of the implant surface, to the complex biological environment is of particular importance. Nearly half a million hip prosthesis are implanted annually world wide. Thereby an implant induced infection still is the complication that is mostly feared. Hence it is vitally important to design implant surfaces in such a way that they act not only cell stimulating but also antibacterial. The formation of biofilms can be suppressed by adding antibiotics on the implant surface which will be released during a specific period. Application of therapeutic antibiotics for local infection prophylaxis is controversial, since the local application leads to increased development of resistances to antibiotics in bacteria.
An alternative solution for the prevention of bacterial colonisation is the incorporation of metal ions into the implant surface. Read more
Within the GEREMA research project the possibilities are investigated to treat very large bone defects which are not curable by the self-healing capacities of the human body. For example large bone defects resulting from tumour resections or severe incidents cannot be cured by the body without any external help. So the defect gap has to be filled with suited materials and tissue metabolism has to be supported. For treatment of such large defects usually bone transplantations will be performed, whereas the donor tissue is autologous tissue from the patients or from allogenous origin. Both methods have a lot of risks and side effects. By the application of autologous grafts it is necessary to set large defects on another location inside the body. The usage of allogenous grafts includes the potential risk of disease transmission e. g. HIV or Hepatitis. Synthetic materials, which are able to meet this challenge, have their limitations in large defects.
At this point the method of tissue engineering will be a suitable solution to achieve a qualitatively sophisticated defect healing. Read more