BONITmatrix® - Clinical Results

Several studies performed at universities and clinics confirm the accelerated bone regeneration as well as the biocompatibility of the biomaterial.

Clinical investigations performed at the University Hospital Heidelberg

Bone regeneration after Sinus augmentation for generation of a compact implant bed

The University of Heidelberg (Department of Oral and Maxillofacial Surgery) has successfully performed the sinus floor augmentation procedure on more than 50 patients with the objective of creating a compact implant bed that enables enossal implant placement. Results from these procedures have exhibited the formation of a compact implant bed that enables enossal implants to be inserted with sufficient primary stability 4 months after sinus floor elevation. BONITmatrix® has been proven to promote bone regeneration and predictable results in relation to its application in sinus floor elevation. Further, the healing time can be reduced, evidently shortening the total duration of the therapy. 

Mertens DGI 2007 - PDF: 700 KB

Mertens EAO 2008 - PDF: 1.1 MB

Mertens EACMF 2008 - PDF: 1 MB

Clinical trial at the University of Rostock

Comparison of BONITmatrix® with a pure ß-TCP based material

Within the framework of a randomized clinical study that was approved by the local ethics commission, DOT compared the characteristics of a synthetic bone graft substitute, which is based on ß-TCP (Cerasorb®, curasan AG), to those of a newly developed bone graft material consisting of ß-TCP, HA and SiO2 (BONITmatrix®, DOT GmbH). This synthetic substitute was used to treat bone voids in the upper and lower jaw. Indications were selected from bone voids that resulted from the excision of wisdom teeth or from the resection of odontogenic cysts. The program was followed up after a period of 12 months. DOT investigated the postoperative level of redness as well as soft tissue swelling by using a semiquantitative three-phase chart. Further, a postoperative X-ray analysis of the void area before the treatment and after 1 day, 1 month and 3 months was used to measure osteogenesis and degradation of the material.
The results of the clinical study have demonstrated that a better level of healing was achieved in the BONITmatrix® group during the early stage of wound healing in comparison to the reference group with the ß-TCP-based material.

DOT GmbH
Charles-Darwin-Ring 1a
18059 Rostock l Germany

Phone: +49 381- 4 03 35-0
Fax: +49 381- 4 03 35-99



 

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