FAQ List BONITmatrix®


1
Is it possible to use the bone graft material in sinus floor elevation without autologous bone chips?
Yes, it is possible to perform sinus floor elevation without adding autologous bone chips. However, due to the osteoinductive potential of the autologous bone chips the regeneration time can be reduced.
2
Is BONITmatrix® completely resorbable?
Yes, BONITmatrix® is resorbed completely during the bone remodelling process.
3
Is it possible to mix BONITmatrix® with physiological saline instead of blood?
BONITmatrix® should be exclusively mixed with the patient's blood. If BONITmatrix® has first contact with other fluids, the nano- and micropores are soaked up and the blood (inclusive the growth factors) cannot penetrate the material. This prevents complete bone regeneration in the void area.
4
Is it necessary to cover exposed nervous tissue before BONITmatrix® is applied?
Yes, exposed nervous tissue must be covered using a membrane before BONITmatrix® is applied to prevent potential injuries of the soft tissue.
5
What should be done if the Schneiderian Membrane is perforated?
If a perforation of the Schneiderian Membrane has occurred during sinus floor elevation, the rupture should be covered with a resorbable membrane before the material is applied.
6
What does one do if there is not enough blood for the mixture?
If one does not have enough blood for the void mixture, venous blood may be used. It is very important to mix the material completely with the patient's own blood.
6
Is it necessary to remove granulation tissue and soft tissue from the void?
Soft tissue and granulation tissue must be completely removed from the void for new bone tissue and complete healing.
7
When should a membrane be applied?
The void area should be covered with a membrane or with intact periosteum to prevent soft tissue (connective tissue) from growing.
9
How long is the shelf life of BONITmatrix®?
BONITmatrix® has a shelf life of 5 years after production. The expiry date is noted on every package.
10
Are there any contra indications for the application of BONITmatrix®?
BONITmatrix® may not be used for patients with wound healing disorders or are receiving therapy that negatively influences bone metabolism. BONITmatrix® should not be used for patients who are being treated with non-steroidal anti-inflammatory agents (NSAIDS), as well as those with on Gluco- and Mineral-corticosteroid therapy. Furthermore, the application of BONITmatrix® is contra indicated for voids in open epiphysial plates (Also see contraindication instruction for use).
11
Is it possible to crush of granulates using a mortar?
No, granulates must not be crushed because this destroys nanostructures as well as microstructures with important functions. If smaller granule size is required, it can be made available (see article overview).
12
Is it possible to re-sterilize the material?
Unfortunately not. BONITmatrix® is gamma-sterilised and is only intended for single use. It must not be resterilised.
13
How does take place the degradation of BONITmatrix® in the defect area?
Degradation of the bone graft material takes place beyond cellular processes. The material will be degraded from inside through bone cells and replaced by new bone tissue. It will be integrated into the active natural bone remodelling process.
14
How long does it take until BONITmatrix® is completely resorbed?
The resorption time of BONITmatrix® is dependent on several factors (e. g. void size, smoker/non smoker, systemic medication etc). A period of 4-8 months is recommended as a guide for complete resorption of the material. The latest scientific and clinical studies show that a substantial level of bone regeneration, which enables the insertion of enossal implants, is achieved after a period of 4 months after sinus floor elevation.
15
Does volume decrease or shrinkage occur during the resorption process?
A marginal decrease in volume occurs during the remodelling process. Therefore, it is necessary to apply the material lightly into the void.
16
When can implants be inserted after they are augmented with BONITmatrix®?
Enossal implants can be inserted into bone tissue that was augmented with BONITmatrix® 3 months after augmentation. A sufficient amount of jaw bone is rebuilt after this period to ensure strong implant anchorage and to guarantee sufficient primary stability.
17
What are the storage requirements of BONITmatrix®?
BONITmatrix® must be stored in the sealed original packaging at room temperature. Storage at lower temperatures is not allowed (see Instruction for use).
18
Are there any known side effects?
BONITmatrix® is not known to be cytotoxic and does not possess sensitising properties (no allergenic potential).
19
Can BONITmatrix® be mixed/applied with antibiotics?
Antibiotics can be administered in combination with BONITmatrix® if the need arises. Its material has a high capacity to absorb antibiotics and is able to store these for a long time period.
20
How much coverage can be achieved with BONITmatrix®?
1 g BONITmatrix® is sufficient to fill a void of approx. 2 cm³.
21
How does one select the right granule size for a void?
The larger granulate size should be selected for larger voids to ensure that there is enough space for new blood vessels and collagen fibers to grow. The smaller granulate size is suitable for smaller voids (e. g. peri implant defects and periodonological voids) However, both granulate sizes are approved for all indications mentioned in the instruction for use. The granule size for a void is selected at the discretion of the surgeon.

DOT GmbH
Charles-Darwin-Ring 1a
18059 Rostock l Germany

Phone: +49 381- 4 03 35-0
Fax: +49 381- 4 03 35-99



 

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