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FAQ List BONITmatrix®
Is it possible to use the bone graft material in sinus floor elevation without autologous bone chips?
Yes, it is possible to perform sinus floor elevation without adding autologous bone chips. However, due to the osteoinductive potential of the autologous bone chips the regeneration time can be reduced.
Is BONITmatrix® completely resorbable?
Yes, BONITmatrix® will be resorbed completely during the bone remodelling process.
Is it possible to mix BONITmatrix® with physiological saline instead of blood?
BONITmatrix® should be exclusively mixed with the patient?s blood. If BONITmatrix® has first contact with other fluids, the nano- and micropores will be soaked up and the blood (inclusive the growth factors) cannot penetrate the material. Consequence of which is a delayed incomplete bone regeneration in the defect area.
Is it necessary to cover exposed nervous tissue before BONITmatrix® is applied?
Yes, exposed nervous tissue must be covered using a membrane before BONITmatrix® is applied to prevent potential injuries of the soft tissue.
What should be done when the Schneiderian Membrane is perforated?
If a perforation of the SchneiderianMembrane has occurred during sinus floor elevation, the rupture should be covered with a resorbable membrane before the application of the material.
What should be done when there is not enough blood at your disposal for mixing?
When there is not enough blood at your disposal for mixing during the defect preparation, the use of venous blood is indicated. It is very important to mix the material completely with patient?s own blood.
Is it necessary to remove granulation tissue and soft tissue from the defect?
Yes, absolutely. To achieve a complete healing of the defect with new bone tissue the defect area must be completely cleaned from soft tissue and granulation tissue.
When should a membrane be applied?
Covering of the defect area should be carried out with a membrane or with intact periosteum to avoid the ingrowth of soft tissue (connective tissue).
How long is the shelf life of BONITmatrix®?
The shelf life of BONITmatrix® is 5 years after fabrication. The expiry date is noted on every package.
Are there any contra indications for the application of BONITmatrix®?
BONITmatrix® may not be used in patients, who exhibit impeded wound healing or are receiving therapy which negatively influences the bone metabolism. In patients taking non- steroidal anti inflammatory agents (NSAIDS), as well as those with existing Gluco- and Mineral-corticosteroid therapy BONITmatrix® should not be applied. Furthermore the application of BONITmatrix® is contra indicated for defects in open epiphysial plates (see also Instruction for use- contraindications).
Is the crushing of granulates using a mortar possible?
No, granulates must not be crushed, because thereby the functional important nano- and microstructures will be destroyed. If there is a smaller granularity required, the material is available in a smaller one (see article overview).
Is it possible to re- sterilise the material?
No. BONITmatrix® is gamma- sterilized and therefore intended only for single use. Resterilisation is not possible.
How does the degradation of BONITmatrix® take place in the defect area?
Degradation of the bone graft material takes place beyond cellular processes. The material will be degraded from inside through bone cells and replaced by new bone tissue. It will be integrated into the active natural bone remodelling process.
How long does it take until BONITmatrix® is completely resorbed?
The resorption time of BONITmatrix® depends on several factors (e. g. defect size, smoker/non smoker, systemic medication etc). As a benchmark a period of 4-8 months can be assumed for a complete resorption of the material. New clinical results have shown even 4 months after sinus floor elevation a good bone regeneration which enables the insertion of enossal implants.
Does volume decrease or shrinkage occur during the resorption process?
During the remodelling process a very marginal volume decrease occurs. Therefore it is necessary to apply the material with a light overage into the defect.
When can the insertion of enossal implants be done after augmentation with BONITmatrix®?
The insertion of enossal implants in bone tissue which was augmented with BONITmatrix® can be carried out 3 months after augmentation. After this period there is enough jaw bone rebuilt for a strong anchorage of the implant to guarantee a sufficient primary stability.
How should BONITmatrix® be stored?
BONITmatrix® must be stored in the sealed original packaging at room temperature. Storage at lower temperatures is not allowed (see Instruction for use).
Are there any known side effects?
BONITmatrix® is not cytotoxic and has no sensitising properties (no allergenic potential).
Can BONITmatrix® be administered with antibiotics?
If there is the necessity for dispensing antibiotics, this can be done in a combination with the application of BONITmatrix®. The material has a high capacity for uptake (besser: absorption??) of antibiotics and is able to store these for a long time period.
How abundant is BONITmatrix®?
1g BONITmatrix® is sufficient to fill a defect of approx. 2cm³.
Which granulate size is indicated for which defect?
Basically, for larger defects (e. g. sinus floor elevations, polymural defects) the bigger granulate size is indicated to ensure that there is enough space for new blood vessels and collagen fibres. For smaller defects (e. g. peri implant defects and periodonological defects) the smaller granulate size is appropriate.
Finally both granulate sizes are approved for all indications mentioned in the instruction for use and it depends on the decision of the surgeon, which granulate size will be taken for which defect.
FAQ List OSSA NOVA
Is OSSA NOVA hardening after contact with body fluids?
No, OSSA NOVA is a non setting material.